SIGNALLING INSIDE WIRED NEURAL NETWORKS: A QUEST FOR PRINCIPLES

Memory formation in the brain is thought to rely on the remodeling of synaptic connections which eventually results in neural network rewiring. This remodeling is likely to involve ultrathin astroglial protrusions which often occur in the immediate vicinity of excitatory synapses. The phenomenology, cellular mechanisms, and causal relationships of such astroglial restructuring remain, however, poorly understood. This is in large part because monitoring and probing of the underpinning molecular machinery on the scale of nanoscopic astroglial compartments remains a challenge. We will discuss recent observations concerning morphological astroglial plasticity, the respective monitoring methods, and some of the newly emerging techniques that might help with conceptual advances in the area. 

Speaker: Professor Dmitri Rusakov, Institute of Neurology, UCL

Host: Andrei Sapelkin

Date: November 11th, 2016 at 16:15

Place: GO Jones Lecture Theatre

Refreshments will be served after the event in the museum